Taking a plasmalogen supplement can help your brain fight Alzheimer’s disease. The supplement works to increase blood levels of DHA-Plasmalogen, a molecule that helps the body process amyloid precursor protein. Using this supplement can help your brain improve memory, cognition, and mobility. It may even help you reduce inflammation in your brain.
Increases non-amyloidogenic processing of amyloid precursor protein
Despite decades of data showing the negative health effects of low plasmalogen levels, there has been no widespread use of plasmalogen in humans. However, in November 2019, a synthetic plasmalogen was approved for human use for the first time.
Plasmalogens are a type of phospholipid that are a part of the synaptic membrane and act as a reservoir for important fatty acids. They also serve as an anti-inflammatory and powerful antioxidant. They are found in very high concentrations in the brain and heart. However, their production and metabolism are compromised as we age. The decrease in plasmalogen levels has been linked to an increased risk of Alzheimer’s disease and dementia.
Plasmalogens are an important structural component of the synaptic membrane and are found in very high concentrations in the heart and brain. They are also highly susceptible to oxidative stress and inflammation. Plasmalogens are degraded during inflammation and oxidative stress, which reduces their ability to protect the brain.
A-secretase and g-secretase are proteases that catalyze the cleavage of amyloid precursor protein (APP). The a-secretase cleavage usually occurs after initial ectodomain shedding, and results in the release of sAPPa. The g-secretase cleavage results in the release of Ab. This cleavage has been shown to initiate intracellular cell signaling.
Improves cognition and mobility in persons diagnosed with mild to moderate cognitive impairment
Several recent clinical studies have demonstrated that a plasmalogen supplement improved cognition and mobility in people diagnosed with mild to moderate cognitive impairment. These studies used highly variable cognitive outcome measures. The most notable aspect of these studies was the short follow-up period.
A pharmacology trial in participants with mild to moderate cognitive impairment was designed to evaluate the pharmacodynamic effects of DHA-AAG. This is a glycerophospholipid that is found in high concentrations in neuronal membranes. Its level is normally lowered in those with Alzheimer’s disease, a condition that afflicts an estimated five percent of adults worldwide. It is believed to be responsible for the severity of the disease.
The study included 22 participants with a range of cognitive impairment, from mild to moderate dementia. The clinical trials were performed at the Neurological Associates Clinic in Santa Monica, CA, and the sample size was small, but the results were promising. The study used a five-month regimen, ranging from 900 to 1800 mg of ProdromeNeuro Plasmalogen Oil per day. A clinical evaluation was performed at the end of each month to gauge relative cognitive and mobility status.
A 10-item questionnaire known as the Quick Dementia Rating System (QDRS) was used to assess cognitive status. QDRS scores ranged from 0 to 30, with higher scores indicating greater cognitive impairment.
Helps with hallucinations
Putting a functional plasmalogen supplement to the test is no easy feat. In fact, it takes some grit and a hefty dose of luck to be able to enjoy the fruits of your labors. After all, the human brain consists of trillions of cells, some of which are dormant and dead. With all that said, it is not surprising that plasmalogens are coveted by the score. The most noteworthy amongst them is the DHA-AAG plasmalogen, which has been shown to outperform the likes of its counterparts. Its most notable virtues include the ability to boost cognitive function in older adults. To achieve the feat, it is necessary to take the proper pharmacotherapy. Hence, it is advisable to consult with a physician to determine which plasmalogen supplement is best suited to your needs.
The best plasmalogen supplement is a well-balanced regimen of vitamins and supplements, all of which should be consumed in moderation. It is recommended that you take the supplement at least three times a day for optimal results. Having a well-balanced bloodstream is essential to preventing neuronal damage. Aside from the bloodstream, the aforementioned supplements also play a role in preventing dementia and memory loss.
Reduces inflammation in the brain
During an aging process, the brain’s immune system attacks synapses. This can negatively affect memory and cognition. Plasmalogen supplementation reduces inflammation and improves memory, learning and performance.
Plasmalogens are antioxidants that are critical to brain health. These molecules are found in the brain and other organs in large concentrations. They are important structural components of synaptic membranes and play a critical role in the brain’s ability to maintain healthy brain conditions.
Plasmalogen levels decrease as the body ages. This decline is associated with a variety of diseases. Plasmalogen deficiency increases the risk of cognitive impairment and neurotoxicity. These declines may be linked to the production of ROS. Degradation of plasmalogens may be associated with neuroinflammation, an important aspect of Alzheimer’s disease. Plasmalogens also decrease the activity of g-secretase, a key regulator of synaptic membrane fluidity. Plasmalogen supplementation was found to alleviate neuroinflammation and reduce synaptic plasticity. Plasmalogens are produced by the liver and are found in high concentrations in the heart and brain.
Plasmalogen supplements may be beneficial in patients with age-related neurological degeneration. These supplements are scientifically designed to maintain plasmalogen levels in the bloodstream. In addition, plasmalogen levels have been found to be associated with cognitive performance, spatial learning and memory.
Increases blood DHA-Plasmalogen levels
Increasing blood DHA-Plasmalogen levels has shown positive effects on oxidative stress biomarkers and cognition. Plasmalogens are a specific type of glycerophospholipid (GPL). Plasmalogens are found in high concentrations in the neuronal membranes and synaptic cleft. They have antioxidant properties that help protect cells from oxidative stress.
Plasmalogens are transported by HDL particles in the blood supply. They have been shown to improve cholesterol clearance and lipid transport. Plasmalogens are particularly abundant in the brain. Deficiencies in plasmalogens are associated with neurodegenerative diseases and heart disease.
Plasmalogens are made in the liver. They are covalently bound to DHA at the sn-2 position. Plasmalogens are degraded by oxidative stress and inflammation. Several epidemiological studies have shown an association between plasmalogen deficiency and cognition. However, the mechanisms underlying the relationship between plasmalogens and cognition remain unclear.
Plasmalogen precursors, 1-O-alkyl-2,3-diacylglycerol (AAG) and DHA-AAG, have been shown to increase blood plasmalogens. These precursors also have neuroprotective properties in animal models of neurodegeneration. AAG plasmalogen precursors also have a species-selective elevating effect on serum ethanolamine phospholipids.
AAG plasmalogen precursor has been shown to normalize serum MDA levels in persons with high baseline MDA. DHA-AAG also normalized serum catalase (CAT) activity in persons with low baseline CAT activity. The effect on serum SOD activity was less clear.
No artificial sweeteners, flavors, or preservatives
Despite widespread belief that artificial sweeteners are beneficial for people with diabetes, obesity, and cardiovascular disease, research shows that they may actually increase risk. The research also indicates that artificial sweeteners may increase the risk of cancer.
In addition to being linked to obesity and diabetes, the use of artificial sweeteners may also contribute to the worldwide rise in pediatric diabetes and obesity. In fact, researchers have found that children who consume artificial sweeteners may have a higher risk of developing heart disease.
The use of artificial sweeteners may also increase the risk of metabolic syndrome. This is a condition where the body becomes inefficient at controlling blood sugar. Symptoms include increased blood pressure and insulin resistance.
Research also suggests that artificial sweeteners may be beneficial for people with multiple sclerosis or chronic fatigue syndrome. They may also help those with Alzheimer’s disease.
Studies also show that artificial sweeteners contribute to metabolic syndrome, the condition that causes a person to become obese or have high blood pressure. These conditions may lead to heart disease, stroke, and diabetes. In addition, they may cause hypoglycemia.
The problem with artificial sweeteners is that the body never learns to expect the sweet taste of sugar. It always looks for balance. That means the body produces insulin in response to the artificial sweetener.
A decrease in plasmalogens may be an effective way to identify AD
During the early stages of AD, a decrease in plasmalogens has been shown to be a promising clinical biomarker. Plasmalogens are essential for cell survival, and they protect cells from damage. They also act as antioxidants. It may be possible to restore plasmalogen levels and delay the onset of AD. This may lead to improvements in cognitive function in AD patients.
Plasmalogens are lipids that are a subtype of phospholipid. They are essential for membrane fluidity, and for the release of neurotransmitters from presynaptic vesicles. Plasmalogens are also important for the process of vesicular fusion.
In the human brain, plasmalogens are primarily found in glial white matter. They are also found in erythrocyte membranes. Plasmalogens have been reported to decrease in many degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis. It has also been reported that plasmalogen levels are decreased in people with metabolic diseases. However, the link between plasmalogens and AD is still unclear.
Plasmalogens are thought to be involved in cholesterol regulation, vesicular fusion, and amyloid precursor protein processing. Plasmalogens are also believed to reduce the activity of the membrane-associated aspartic protease, g-secretase. G- secretase is a cytosolic enzyme that catalyzes the final step of the Ab synthesis.
